VasoPT Bioscience Limited
Book a demo
Home / Applications

One method, three safety questions

Small molecules, nanomaterials, environmental chemicals — different test articles, yet the decision output sits on one comparable table.

Case 01

Cardiovascular toxicity assessment and
risk stratification of 500 small molecules

With a large candidate library, the goal is not to explain each compound individually but to surface and rank risk signals within a limited time.

Test article
500 small molecules / candidate library
Objective
Identify potential cardiovascular toxicity risk and stratify it
Analysis
Multi-region vascular phenotype, composite score, dose response, sensitive regions
Output
Low / intermediate / high risk strata and a watch list
Risk stratification (example) n = 500
High risk78 · 15.6%
Intermediate162 · 32.4%
Low risk260 · 52.0%
Example · composite risk score
0 / 100
Intermediate-high

High risk: clear cardiovascular toxicity signals; intermediate: potential risk requiring attention; low: no clear risk signal, comparatively good safety.

Case 02

Cardiovascular safety assessment of
black phosphorus materials and nano drug-delivery systems

Nanomaterial risk rarely lies in "toxic or not" but in the combination of dose, exposure route and local structural injury. It has to be observed at the level of the whole circulation.

Test article
Black phosphorus nanomaterials, quantum dots and related nano drug-delivery systems
Observation point
48 hpf zebrafish cardiovascular phenotype visualization
Objective
Focus on vascular developmental abnormalities, local structural injury and dose-related risk
Output direction
Safety grading, dose-range guidance, sensitive endpoints and optimization reference
Cardiovascular safety dashboard (example) Relative to control
0Heart rate · bpm
↓ 12%
0Blood flow velocity
↓ 8%
0Microvessel density
↓ 15%
0Regional injury
↑ 18%

Readouts illustrate the dashboard format; values vary with sample, dose and batch and do not represent fixed conclusions.

Suggested safety gradingExample
Low riskRecommended range
Mild riskUse with caution
Moderate riskManageable risk
High riskAvoid use
Case 03

Vascular toxicity profile of
150 chemicals of environmental health concern

When sample numbers and structural diversity are high, the value lies not in single conclusions but in clusterable injury patterns and a rankable risk list.

Test article
150 chemicals of environmental health concern
Categories covered
Pesticides, BTEX aromatics, heavy metals, perfluorinated compounds, PAHs and more
Technical system
High-content imaging, AI recognition, multi-dimensional vascular structure metrics and composite scoring
Key finding
Chemicals show varying degrees of vascular toxicity and injury characteristics
Six vascular injury phenotypes Pattern recognition result
Development inhibition Malformation / hyperplasia Circulatory impairment Mixed injury Increased permeability Regional injury
Vascular toxicity ranking (composite score, illustrative)
Sample A86
Sample B54
Sample C21

Clustering and ranking compress many samples into an actionable list; grouping thresholds follow the criteria set for the project.

About the case data Compound counts, stratum proportions and readouts come from platform demonstration material and illustrate deliverable format and analytical dimensions; they do not constitute toxicity conclusions for any specific compound or material. Actual projects report under the agreed protocol.

Which design fits your samples?

Tell us the sample type, number and target endpoints, and we will propose the dose design and deliverable list.

Book a demo View the technology platform